Welcome to the openGUTS information pages
OpenGUTS is a user-friendly
software to perform analyses with GUTS: the General Unified
Threshold model for Survival. GUTS is the leading
toxicokinetic-toxicodynamic framework for the endpoint
survival (and other non-reversible all-or-nothing effects).
This site hosts the software itself, as a standalone Windows
executable, with manuals and background documentation. Since
openGUTS is (as the name implies) open source, also the
source files can be obtained here. Additionally, you can
download the Matlab version, which served as the blueprint
for the standalone version. The Matlab version has basically
the same functionality, and can be easily adapted or
extended to perform customised analyses. Finally, we provide
(links to) further information on openGUTS and GUTS.
The main features of the software are:
- Open and free: the software is open source and
freely downloadable. The fully-functional Matlab version that
served as the prototype is also available.
- User-friendly: fit models and derive
confidence intervals without requiring user interaction
(e.g., no need for starting values).
- Robust: always find the global optimum and
relevant intervals, even for awkward data sets.
- Flexible: allow time-varying exposure, missing
data, simultaneous fitting on multiple data sets, etc.
- Efficient: rapid screening of exposure profiles
output) by batch processing.
- Supportive: the software follows the workflow
as laid down in the 2018
EFSA opinion on TKTD models.
real error found. The IT calculations use a
shortcut that does not work in all cases. This error will
affect IT calibrations for time varying exposure,
where the exposure scenario includes episodes of linear
decrease over time (for constant exposure and block pulses,
it will be fine). It will also affect IT LPx predictions
when the exposure scenario is specified with a crude
resolution (the hourly resolution of FOCUS profiles will
lead to negligible errors). This error will be repaired in
the next update of the Matlab version, to v. 1.1, which will
be soon. Download
a PDF document explaining this error in detail. (posted
19 May 2019)
openGUTS standalone Windows executable
openGUTS in Matlab
- 20 May 2020: document explaining the error linked to
the error warning (on this page above, and on the
downloads page). Also updated the 'list of known issues'
with this error, and a few more small GUI bugs.
- 20 May 2020: openGUTS on-line, completely-DIY, short
course is now available. See course
- 19 May 2020: error found in the IT calculations. More
information and workarounds/repairs coming soon.
- 10 May 2020: small update to the interpretation
document, adding a section with a brief description of
the model and its parameters (and what they do).
Furthermore some small textual changes and error repair.
- 21 April 2020: updated the "list with known issues"
with a few small bugs and additional items for the
wishlist. See download page.
- We will provide a half-day short course on the
openGUTS software at the virtual SETAC Europe in May
2020. See the
SETAC web page, and scroll down to "TC11 -
Introduction to Effect Modelling with the User-Friendly
Software OpenGUTS." We need to see how SETAC will
support the short courses on-line, so more information
will follow. There will also be a poster on openGUTS at
this conference (ID 4.07P.4).
- 12 December 2019: added the source code and an updated
version of the design document. See download page.
- 10 December 2019: version 1.0 of the standalone is
available for download (with manual, but not yet with
the source code). Furthermore, a new version of the
Matlab version (previously known as the prototype). Also
updates of the manuals and for several of the background
documents. See download page.
- 4 November 2019: update for the openGUTS prototype in
Matlab, and small update to its manual and design doc.
See download page.
- 18 Sept. 2019: the planned course
on openGUTS in October 2019 has been cancelled.
Unfortunately, we had insufficient registrations.
- 30 Aug. 2019: small update to the design and
interpretation documents on the download
- 22 July 2019: update of the test document (includes
ring test but also additional data sets with difficult
properties). See download page.
- 12 July 2019: another update of the prototype, solving
a few minor bugs and adding some nice features (wait
bars and error boxes). See download
- 23 May 2019: tiny update of the prototype. It now
includes the same set of exposure profiles as used in
the EFSA scientific opinion. See download page.
- 22 May 2019: added a walkthrough
through the code of the prototype (made with Matlab's
- 21 May 2019: a number of background documents are
- 17 May 2019: first release of the openGUTS prototype
in Matlab. See download page.
- 14 May 2019: the website is online! Not all pages are
completely filled at this point ....