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Supporting mechanistic modelling for survival

DEBtox Researc



On-line short course



On-line open
GUTS short course. Roman Ashauer and Tjalling Jager have provided an on-line half-day short course on the openGUTS software at the virtual SETAC in May 2020. Since SETAC was virtual this year, we also had the course on-line, with a mixture of on-demand lectures, homework exercises, and plenary video sessions. Tjalling has now turned this material into a publicly-available on-line short course at Leanpub: https://leanpub.com/c/openguts. This version does not include interaction with the instructors (so it is completely DIY), but we have added some quizzes to test your skills with openGUTS. Note that this course is not free, though you can simply obtain a refund from Leanpub if you think the course was not worth its price.

Dedicated openGUTS course



Regular GUTS courses. We intend to provide a regular 2-day course in Wageningen (The Netherlands) on using GUTS in risk assessment of plant protection products. This course will apply the openGUTS standalone software (and the Matlab version as well, if there is a specific interest). However, we do not have a date planned to run this course; in view of the corona crisis, it will likely not be earlier than 2021.

Target audience. This course aims at professionals interested in applying GUTS for the authorisation of plant protection products (PPPs):
  • Consultants and business representatives working for industry and/or consulting agencies who apply GUTS for dossiers (evaluation, preparation and submission).
  • Scientists performing research on TKTD modelling with interest in GUTS applications in risk assessment.
  • Regulators working for admission authorities who evaluate dossiers containing GUTS applications or are in general interested in an improved link between exposure and effects.
Content & Result. The course focuses on the application of GUTS models for assessing the risk of plant-protection products (PPP) under time-variable exposure in aquatic systems. GUTS is the accepted toxicokinetic-toxicodynamic approach for the endpoint survival. The theory behind GUTS models will be introduced and course participants will learn how to use the latest implementation of the GUTS models in openGUTS; a user-friendly standalone software. Furthermore, they will practice assessing the results and learn how to interpret them. Hands-on exercises include model calibration and validation, and model predictions in consideration of the recommendations given by EFSA. Participants should at least hold a Bachelor degree or similar in natural sciences, and have some experience with the use of models, preferably in risk assessment.

Practical information.
Location: Wageningen, The Netherlands (we will arrange a shuttle service from the train station Ede-Wageningen)
Dates: to be determined
Course leader: Dr Andreas Focks (Wageningen Environmental Research)
Lecturers: Dr Roman Ashauer (Syngenta) and Dr Tjalling Jager (DEBtox research)
Maximum number of participants: 30

Course fee: € to be determined (no charge of VAT); covers tuition, course materials, coffee/tea, lunches, 2 dinners.
Employees of an admission authority/university can apply for a reduced course fee.
Traveling and accommodation costs are not included.
A few places at a strongly reduced fee are available for PhD students, please contact the course leader for more information.

Registration: to be announced. Registration and payment is handled by Wageningen UR.

On-site GUTS courses. Apart from the 2-day open course in Wageningen, we also intend to offer the course on-site at your offices. This may be an interesting option for authorities or industries that have more employees that need to be familiarised with the model and the software. We are still thinking about the format and the pricing for this option, but you may contact Tjalling Jager (see email at the bottom of this page) to discuss this.

Other interesting courses and events


  • We will organise the Summerschool on TKTD modelling again in August 2021, likely in a similar format to the previous runs. Information on the previous runs of this course. (note that there will not be a course in 2020 due to the corona situation)













The openGUTS project, www.openguts.info. This site is maintained by Tjalling Jager, email: tjalling (at) debtox.nl