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Supporting mechanistic modelling for survival

DEBtox Researc



Old news from home page


  • 9 January 2021: Best wishes for the new year! Forgot to provide the link to the new paper on the algorithm used in openGUTS for calibration and error propagation. It is still only available in 'early view': DOI: 10.1002/ieam.4333
  • 29 August 2020: The general statistical framework and the automated optimisation algorithm as developed for openGUTS have been described in detail in a manuscript, including an extensive supporting information. This manuscript has been accepted for publication in IEAM; a link will be provided here when the paper is available on-line.
  • 26 May 2020: update of the Matlab version of openGUTS. This version 1.1 repairs the error that was discovered (the standalone still has this error, so do take a look at the dedicated document for this error). See download page.
  • 20 May 2020: document explaining the error linked to the error warning (on this page above, and on the downloads page). Also updated the 'list of known issues' with this error, and a few more small GUI bugs.
  • 20 May 2020: openGUTS on-line, completely-DIY, short course is now available. See course page.
  • 19 May 2020: error found in the IT calculations. More information and workarounds/repairs coming soon.
  • 10 May 2020: small update to the interpretation document, adding a section with a brief description of the model and its parameters (and what they do). Furthermore some small textual changes and error repair.
  • 21 April 2020: updated the "list with known issues" with a few small bugs and additional items for the wishlist. See download page.
  • We will provide a half-day short course on the openGUTS software at the virtual SETAC Europe in May 2020. See the SETAC web page, and scroll down to "TC11 - Introduction to Effect Modelling with the User-Friendly Software OpenGUTS." We need to see how SETAC will support the short courses on-line, so more information will follow. There will also be a poster on openGUTS at this conference (ID 4.07P.4).
  • 12 December 2019: added the source code and an updated version of the design document. See download page.
  • 10 December 2019: version 1.0 of the standalone is available for download (with manual, but not yet with the source code). Furthermore, a new version of the Matlab version (previously known as the prototype). Also updates of the manuals and for several of the background documents. See download page.
  • 4 November 2019: update for the openGUTS prototype in Matlab, and small update to its manual and design doc. See download page.
  • 18 Sept. 2019: the planned course on openGUTS in October 2019 has been cancelled. Unfortunately, we had insufficient registrations.
  • 30 Aug. 2019: small update to the design and interpretation documents on the download page.
  • 22 July 2019: update of the test document (includes ring test but also additional data sets with difficult properties). See download page.
  • 12 July 2019: another update of the prototype, solving a few minor bugs and adding some nice features (wait bars and error boxes). See download page.
  • 23 May 2019: tiny update of the prototype. It now includes the same set of exposure profiles as used in the EFSA scientific opinion. See download page.
  • 22 May 2019: added a walkthrough through the code of the prototype (made with Matlab's publish option).
  • 21 May 2019: a number of background documents are already downloadable.
  • 17 May 2019: first release of the openGUTS prototype in Matlab. See download page.
  • 14 May 2019: the website is online! Not all pages are completely filled at this point ....


The openGUTS project, www.openguts.info. This site is maintained by Tjalling Jager, email: tjalling (at) debtox.nl