Welcome to the openGUTS information pages
OpenGUTS is a user-friendly
software to perform analyses with GUTS: the General Unified
Threshold model for Survival. GUTS is the leading
toxicokinetic-toxicodynamic framework for the endpoint
survival (and other non-reversible all-or-nothing effects).
Version 1.0 was released in December 2019.
This site hosts the software itself, as a standalone Windows
executable, with manuals and background documentation. Since
openGUTS is (as the name implies) open source, also the
source files can be obtained here. Additionally, you can
download the Matlab version, which served as the blueprint
for the standalone version. The Matlab version has basically
the same functionality, and can be easily adapted or
extended to perform customised analyses. Finally, we provide
(links to) further information on openGUTS and GUTS.
The main features of the software are:
- Open and free: the software is open source and
freely downloadable. The fully-functional Matlab version that
served as the prototype is also available.
- User-friendly: fit models and derive
confidence intervals without requiring user interaction
(e.g., no need for starting values).
- Robust: always find the global optimum and
relevant intervals, even for awkward data sets.
- Flexible: allow time-varying exposure, missing
data, simultaneous fitting on multiple data sets, etc.
- Efficient: rapid screening of exposure profiles
output) by batch processing.
- Supportive: the software follows the workflow
as laid down in the 2018
EFSA opinion on TKTD models.
real error found. The IT calculations use a
shortcut that does not work in all cases. This error will
affect IT calibrations for time varying exposure,
where the exposure scenario includes episodes of linear
decrease over time (for constant exposure and block pulses,
it will be fine). It will also affect IT LPx predictions
when the exposure scenario is specified with a crude
resolution (the hourly resolution of FOCUS profiles will
lead to negligible errors). This error is repaired in the
update of the Matlab version, to v. 1.1. Download a PDF
document explaining this error in detail. (posted
19 May 2019)
openGUTS standalone Windows executable
openGUTS in Matlab
- 29 August 2020: The general statistical framework and
the automated optimisation algorithm as developed for
openGUTS have been described in detail in a manuscript,
including an extensive supporting information. This
manuscript has been accepted for publication in IEAM; a
link will be provided here when the paper is available
- 26 May 2020: update of the Matlab version of openGUTS.
This version 1.1 repairs the error that was discovered
(the standalone still has this error, so do take a look
at the dedicated document for this error). See download page.
- 20 May 2020: document explaining the error linked to
the error warning (on this page above, and on the
downloads page). Also updated the 'list of known issues'
with this error, and a few more small GUI bugs.
- 20 May 2020: openGUTS on-line, completely-DIY, short
course is now available. See course
- 19 May 2020: error found in the IT calculations. More
information and workarounds/repairs coming soon.
- 10 May 2020: small update to the interpretation
document, adding a section with a brief description of
the model and its parameters (and what they do).
Furthermore some small textual changes and error repair.
- 21 April 2020: updated the "list with known issues"
with a few small bugs and additional items for the
wishlist. See download page.
- We will provide a half-day short course on the
openGUTS software at the virtual SETAC Europe in May
2020. See the
SETAC web page, and scroll down to "TC11 -
Introduction to Effect Modelling with the User-Friendly
Software OpenGUTS." We need to see how SETAC will
support the short courses on-line, so more information
will follow. There will also be a poster on openGUTS at
this conference (ID 4.07P.4).
For old news items, click here.