Welcome to the openGUTS information pages
OpenGUTS is a user-friendly
software to perform analyses with GUTS: the General Unified
Threshold model for Survival. GUTS is the leading
toxicokinetic-toxicodynamic framework for the endpoint
survival (and other non-reversible all-or-nothing effects).
Version 1.0 was released in December 2019, followed by
Version 1.1. in February 2021.
This site hosts the software itself, as a standalone Windows
executable, with manuals and background documentation. Since
openGUTS is (as the name implies) open source, also the
source files can be obtained here. Additionally, you can
download the Matlab version, which served as the blueprint
for the standalone version. The Matlab version has basically
the same functionality, and can be easily adapted or
extended to perform customised analyses. Finally, we provide
(links to) further information on openGUTS and GUTS.
The main features of the software are:
- Open and free: the software is open source and
freely downloadable. The fully-functional Matlab version that
served as the prototype is also available.
- User-friendly: fit models and derive
confidence intervals without requiring user interaction
(e.g., no need for starting values).
- Robust: always find the global optimum and
relevant intervals, even for awkward data sets.
- Flexible: allow time-varying exposure, missing
data, simultaneous fitting on multiple data sets, etc.
- Efficient: rapid screening of exposure profiles
(e.g., FOCUS
output) by batch processing.
- Supportive: the software follows the workflow
as laid down in the 2018
EFSA opinion on TKTD models.
Error
in v1.0. The IT calculations use a shortcut
that does not work in all cases. This error will affect IT calibrations
for time varying exposure, where the exposure scenario
includes episodes of linear decrease over time (for constant
exposure and block pulses, it will be fine). It will also
affect IT LPx predictions when the exposure
scenario is specified with a crude resolution (the hourly
resolution of FOCUS profiles will lead to negligible
errors). This error is repaired in the update of the Matlab
version, to v. 1.1. Download a PDF
document explaining this error in detail. (posted
19 May 2020). This error is repaired in the update of
the standalone and Matlab version, to v. 1.1.
New version of the
standalone launched (v1.1). The openGUTS
standalone has been updated: the error has been fixed and
extended batch capabilities have been included.
New installation file for
the standalone (v1.1). The installation file
for the openGUTS standalone has been updated: the version of
Feb. 2021 triggered a (false-positive) trojan warning by
some virus scanners. We changed the packaged file docto.exe
(which creates the reports) to its latest version (v. 1.8),
which does not trigger this virus warning. The code for the
openGUTS calculations has not changed, and there was no new
compilation of the C++ code. The only change is thus a
re-packaging with the new docto.exe. Downside is that the
line spacing in the produced reports is increased, which
does not look so nice. However, that is easily modified
manually in the Word version of the report that is produced.
If you have successfully installed openGUTS v. 1.1 with the
previous installer, there is no need to update your
installation.
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openGUTS standalone Windows executable
openGUTS in Matlab
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