Welcome to the openGUTS information pages
OpenGUTS is a user-friendly
software to perform analysis with GUTS: the General Unified
Threshold model for Survival. GUTS is a
toxicokinetic-toxicodynamic model for the endpoint survival
(and other non-reversible all-or-nothing effects).
This site hosts the software itself, as a standalone Windows
executable, with manuals and background documentation. Since
openGUTS is (as the name implies) open source, also the
source files can be obtained here. Additionally, you can
download the Matlab prototype here, which served as the
blueprint for the standalone version. The prototype has
basically the same functionality, and can be easily adapted
to perform alternative analyses. Finally, we provided (links
to) further information on openGUTS and GUTS.
The main features of the software are:
- Open and free: the software is open source and
freely downloadable. The fully-functional Matlab prototype is
- User-friendly: fit models and derive
confidence intervals without requiring user interaction
(e.g., no need for starting values).
- Robust: always find the global optimum and
relevant intervals, even for awkward data sets.
- Flexible: allow time-varying exposure, missing
data, simultaneous fitting on multiple data sets, etc.
- Efficient: rapid screening of exposure profiles
output) by batch processing.
- Supportive: the software follows the workflow
as laid down in the 2018
EFSA opinion on TKTD models.
Note: the openGUTS standalone is not yet available for
download (expected by the end of 2019). However, the
fully-functional Matlab prototype is. More
downloadable documentation will be added later in
openGUTS standalone Windows executable
openGUTS prototype in Matlab